THJ-2201

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Summary sheet: THJ-2201
THJ-2201
THJ-2201.svg
Chemical Nomenclature
Common names THJ-2201
Systematic name 1-​[(5-​fluoropentyl)-​1H-​indazol-​3-​yl](naphthalen-​1-​yl)methanone
Class Membership
Psychoactive class Cannabinoid
Chemical class Naphthoylindazole
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.


Smoked
Dosage
Threshold < 0.5 mg
Light 0.5 - 1 mg
Common 1 - 2 mg
Strong 2 - 5 mg
Heavy 5 mg +
Duration
Total 1 - 2 hours
Onset 5 - 10 minutes
Peak 30 - 45 minutes
Offset 0 - 0 minutes (Abrupt)
After effects 60 - 90 minutes










DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

Interactions
2C-T-x
2C-x
5-MeO-xxT
Amphetamines
aMT
Cocaine
DMT
DOx
LSD
Mescaline
Mushrooms
25x-NBOMe
Lithium


THJ-2201 (1-​[(5-​fluoropentyl)-​1H-​indazol-​3-​yl](naphthalen-​1-​yl)methanone) is a synthetic cannabinoid and analog of AM-2201. It has been marketed by many research chemical vendors as a legal alternative to the popular AM-2201, which had been banned in 2011.

Cannabinoids are commonly smoked or vaporized to achieve a quick onset of effects and rapid offset. THJ-2201 is orally active when dissolved in a lipid, which can increase the duration significantly. Like other cannabinoids, it is insoluble in water but dissolves in ethanol and lipids.

Unlike cannabis, the chronic abuse of synthetic cannabinoids has been associated with multiple deaths and more dangerous side effects and toxicity in general. Therefore, it is strongly discouraged to take this substance for extended periods of time or in excessive doses.

Chemistry

THJ-2201, or 1-​[(5-​fluoropentyl)-​1H-​indazol-​3-​yl](naphthalen-​1-​yl)methanone, is a synthetic cannabinoid drug containing a substituted indazole group. This indazole moeity is substituted at R1 with a fluoropentyl chain, a substitution shared with 5F-PB-22 and 5F-AKB48. Additionally, the indazole core is substituted at R3 with a carbonyl group which is also bonded to a napthalene moeity. Napthalene is a bicyclic structure of two fused benzene rings, and is also found in THJ-018. The carbonyl bridge of THJ-2201 classifies it as a ketone. THJ-2201 is an analog of AM-2201 in which the core indole structure is substituted with an indazole base.

Pharmacology

Although this substance has not been formally studied, from analysis of the structure, it is presumed that THJ-2201 has a similar binding profile to that of AM-2201 and matches many of the in vivo properties of Δ9-THC. As with AM-2201, this compound is believed to act as a potent full agonist to the central CB1 and peripheral CB2 receptors with Ki values of 1.0 and 2.6nM respectively. However, the role of these interactions and how they result in the cannabinoid high experience continues to remain elusive.

Subjective effects

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Physical effects
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Visual effects
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Cognitive effects
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Auditory effects
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Combinational effects

  • Psychedelics - When used in combination with psychedelics, cannabinoids are capable of intensifying and extending the duration of both the visual and cognitive effects with extreme efficiency. This should be used with caution if one is not experienced with psychedelics.
  • Dissociatives - When used in combination with dissociatives, the geometry, euphoria, dissociation and hallucinatory effects are often greatly enhanced.
  • Alcohol - When used in combination with alcohol, cannabinoids can cause feelings of extreme nausea, dizziness and changes in gravity. It is recommended that people smoke before drinking and not the other way around unless they are extremely cautious.

Toxicity and harm potential

The toxicity and long-term health effects of recreational THJ-2201 use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because THJ-2201 has very little history of human usage. Anecdotal evidence from people who have tried THJ-2201 within the community suggest that there do not seem to be any negative health effects attributed to simply trying this drug at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed).

Informal experiments have shown that overdose will cause physical discomfort including heart palpitations, vertigo and sedation at much lower than dangerous doses, usually causing the user to suffer moderate to severe anxiety or fall asleep.

It has often been recommended that those with severe pre-existing mental conditions should not ingest these substances due to the way they strongly increase one's current state of mind and emotions. Also, like THC, prolonged usage of synthetic cannabinoids may increase one's disposition to mental illness and psychosis[5], particularly in vulnerable individuals with risk factors for psychotic illnesses (like a past or family history of schizophrenia).[6][7][8]

As synthetic cannabinoids are active in the milligram range (with below 5mg being a common dose), it is important to use proper precautions when dosing to avoid a negative experience.

It is strongly recommended that one use harm reduction practices when using this drug.

Tolerance and addiction potential

As with other synthetic cannibanoids, the chronic use of THJ-2201 can be considered moderately addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage.

Tolerance to many of the effects of THJ-2201 develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the absence of further consumption). THJ-2201 presents cross-tolerance with all cannabinoids, meaning that after the consumption of THJ-2201 all cannabinoids will have a reduced effect.

Dangerous interactions

Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

  • 2C-T-x
  • 2C-x
  • 5-MeO-xxT
  • Amphetamines - Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences
  • aMT
  • Cocaine - Stimulants increase anxiety levels and the risk of thought loops which can lead to negative experiences
  • DMT
  • DOx
  • Lithium - Lithium is commonly prescribed in the treatment of bipolar disorder; however, there is a large body of anecdotal evidence that suggests taking it with cannabinoids can significantly increase the risk of psychosis and seizures. As a result, this combination should be strictly avoided.
  • LSD
  • Mescaline
  • Mushrooms
  • 25x-NBOMe

Legal status

THJ-2201 was developed to bypass drug prohibition laws which have banned the possession and sale of many synthetic cannabinoids. As such, it remains legal in most of the world.

  • Denmark: As of August 25, 2015, THJ-2201 is listed on the list of controlled drugs in Denmark.[10]
  • Germany: THJ-2201 is controlled under Anlage II BtMG (Narcotics Act, Schedule II)[11] as of December 13, 2014.[12] It is illegal to manufacture, possess, import, export, buy, sell, procure or dispense it without a license.[13]
  • Latvia: THJ-2201 is a Schedule I controlled substance.[14]
  • Sweden: THJ-2201 is a controlled substance in Sweden.[15]
  • Switzerland: THJ-018 is a controlled substance specifically named under Verzeichnis E.[16]
  • United Kingdom: THJ-2201 is a Class B controlled substance under the third-generation synthetic cannabinoids generic definition, which came into effect on December 14, 2016 and is illegal to possess, produce, supply, or import.[17]
  • United States: THJ-2201 is a Schedule I controlled substance.[18]

See also

External links

References

  1. Mechoulam, R., ed. (1986). Cannabinoids as therapeutic agents. CRC Press. ISBN 9780849357725. 
  2. 2.0 2.1 How Marijuana Works, 2001 
  3. Martín-Sánchez, E., Furukawa, T. A., Taylor, J., Martin, J. L. R. (November 2009). "Systematic Review and Meta-analysis of Cannabis Treatment for Chronic Pain". Pain Medicine. 10 (8): 1353–1368. doi:10.1111/j.1526-4637.2009.00703.x. ISSN 1526-2375. 
  4. Lynch, M. E., Campbell, F. (November 2011). "Cannabinoids for treatment of chronic non-cancer pain; a systematic review of randomized trials: Cannabinoids for pain". British Journal of Clinical Pharmacology. 72 (5): 735–744. doi:10.1111/j.1365-2125.2011.03970.x. ISSN 0306-5251. 
  5. 5.0 5.1 Arseneault, L., Cannon, M., Witton, J., Murray, R. M. (February 2004). "Causal association between cannabis and psychosis: examination of the evidence". The British Journal of Psychiatry. 184 (2): 110–117. doi:10.1192/bjp.184.2.110. ISSN 0007-1250. 
  6. 6.0 6.1 Every-Palmer, S. (September 2011). "Synthetic cannabinoid JWH-018 and psychosis: An explorative study". Drug and Alcohol Dependence. 117 (2–3): 152–157. doi:10.1016/j.drugalcdep.2011.01.012. ISSN 0376-8716. 
  7. 7.0 7.1 Schneir, A. B., Cullen, J., Ly, B. T. (1 March 2011). ""Spice" Girls: Synthetic Cannabinoid Intoxication". The Journal of Emergency Medicine. 40 (3): 296–299. doi:10.1016/j.jemermed.2010.10.014. ISSN 0736-4679. 
  8. 8.0 8.1 Vearrier, D., Osterhoudt, K. C. (June 2010). "A Teenager With Agitation: Higher Than She Should Have Climbed". Pediatric Emergency Care. 26 (6): 462–465. doi:10.1097/PEC.0b013e3181e4f416. ISSN 0749-5161. 
  9. Zheng, Y., Stiles, L., Hamilton, E., Smith, P. F., Darlington, C. L. (1 September 2010). "The effects of the synthetic cannabinoid receptor agonists, WIN55,212-2 and CP55,940, on salicylate-induced tinnitus in rats". Hearing Research. 268 (1): 145–150. doi:10.1016/j.heares.2010.05.015. ISSN 0378-5955. 
  10. Bekendtgørelse om euforiserende stoffer - ni nye stoffer tilføjet 
  11. "Anlage II BtMG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 30, 2019. 
  12. "Achtundzwanzigste Verordnung zur Änderung betäubungsmittelrechtlicher Vorschriften" (PDF). Bundesgesetzblatt Jahrgang 2014 Teil I Nr. 57 (in German). Bundesanzeiger Verlag. December 12, 2014. pp. 1999–2002. Retrieved December 19, 2019. 
  13. "§ 29 BtMG" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 19, 2019. 
  14. Zaudējis spēku - Noteikumi par Latvijā kontrolējamajām narkotiskajām vielām, psihotropajām vielām un prekursoriem 
  15. http://www.folkhalsomyndigheten.se/nyheter-och-press/nyhetsarkiv/2014/november/cannabinoider-foreslas-bli-klassade-som-halsofarlig-vara/
  16. "Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien" (in German). Bundeskanzlei [Federal Chancellery of Switzerland]. Retrieved January 1, 2020. 
  17. The Misuse of Drugs Act 1971 (Amendment) Order 2016 
  18. "Schedules of controlled substances: temporary placement of three synthetic cannabinoids into schedule I. Final order" (PDF). Federal Register. Office of the Federal Register. 80 (20): 5042–5047. January 30, 2015. PMID 25730924. Archived from the original (PDF) on July 12, 2015. Retrieved January 1, 2020.