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Summary sheet: HXE
Chemical Nomenclature
Common names HXE
Substitutive name 3-HO-2'-Oxo-PCE
Systematic name 2-(Ethylamino)-2-(3-hydroxyphenyl)cyclohexan-1-one
Class Membership
Psychoactive class Dissociative
Chemical class Arylcyclohexylamine
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.

Threshold 30 mg
Light 30 - 60 mg
Common 60 - 100 mg
Strong 100 - 130 mg
Heavy 130 mg +
Total 3 - 8 hours
Onset 20 - 60 minutes
Come up 30 - 60 minutes
Peak 2 - 4 hours
Offset 3 - 6 hours
After effects 1 - 12 hours

Threshold 30 mg
Light 30 - 60 mg
Common 60 - 100 mg
Strong 100 - 130 mg
Heavy 130 mg +
Total 3 - 6 hours
Onset 20 - 60 minutes
Come up 30 - 60 minutes
Peak 2 - 4 hours
Offset 2 - 6 hours
After effects 1 - 12 hours
Threshold 20 mg
Light 40 - 20 mg
Common 40 - 70 mg
Strong 70 - 120 mg
Heavy 120 mg +
Total 3 - 6 hours
Onset 10 - 30 minutes
Come up 20 - 40 minutes
Peak 1.5 - 4 hours
Offset 2 - 4 hours
After effects 2 - 7 hours

DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.


3-HO-2'-Oxo-PCE (commonly known as HXE) is a novel dissociative substance of the arylcyclohexylamine class that produces ketamine-like dissociative effects when administered. It is structurally related to Methoxetamine, Ketamine and PCE.

Limited data exists about the pharmacological properties, metabolism, and toxicity of HXE in humans, and it has a limited history of human use. It is highly advised to use harm reduction practices if using this substance.

History and culture

HXE first appeared for sale on the online research chemical market in late 2020. However, it has been announced about three years prior where it has been 'hyped' for a long time but was on hold due to synthesis difficulties.[citation needed]


HXE or 2-(Ethylamino)-2-(3-hydroxyphenyl)cyclohexan-1-one is classed as an Arylcyclohexylamine

It is substituted on the cyclohexane ring with an oxygen at the 2' position and a hydroxy group at the 3 position on the phenyl ring. In contrast, MXE is substituted there with a methoxy group.


Very little is known about the pharmacology about this substance, however as an arylcyclohexamine it is reasonable to assume that it is an NMDA receptor antagonist. NMDA receptors allow for electrical signals to pass between neurons in the brain and spinal column; for the signals to pass, the receptor must be open. Dissociatives close the NMDA receptors by blocking them. This disconnection of neurons leads to loss of feeling, difficulty moving, and eventually an almost identical equivalent of the famous “k-hole.”

Subjective effects

This subjective effects section is a stub.

As such, it is still in progress and may contain incomplete or wrong information.

You can help by expanding or correcting it.

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

HXE's effects resemble rather the effects of MXPr, MXE, DCK than more chaotic derivatives like O-PCE or MXiPr. Compared to MXE, it has less of a warmth to it and is weaker in its euphoria and clearheadedness, which can roughly be considered equal to MXPr's potency.

Physical effects

Visual effects

Cognitive effects

Disconnective effects

Experience reports

There are currently 0 experience reports which describe the effects of this substance in our experience index.

Toxicity and harm potential


This toxicity and harm potential section is a stub.

As a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it.
Note: Always conduct independent research and use harm reduction practices if using this substance.

The toxicity and long-term health effects of recreational HXE use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because HXE has very little history of human usage.

It is strongly recommended that one use harm reduction practices when using this substance.

Lethal dosage

The lethal dosage of HXE is not known. Based on it's effect it could probably be assumed, that it might carry roughly the same risk of death like similar compounds like DMXE or MXPr.

Tolerance and addiction potential

As with other nmda receptor antagonists, the chronic use of HXE can be considered moderately addictive with a high potential for abuse and is capable of producing psychological dependence among certain users. when addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage.

tolerance to many of the effects of HXE develops with prolonged and repeated use. this results in users having to administer increasingly large doses to achieve the same effects. after that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the absence of further consumption).

HXE presents cross-tolerance with all dissociatives, meaning that after the consumption of HXE all dissociatives will have a reduced effect.

Dangerous interactions


This dangerous interactions section is a stub.

As such, it may contain incomplete or invalid information. You can help by expanding upon or correcting it.

Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

Legal status


This legality section is a stub.

As such, it may contain incomplete or wrong information. You can help by expanding it.

  • Switzerland: HXE can be considered a specially defined derivative of PCE or O-PCE and is therefore illegal.[1]
  • United Kingdom: HXE is illegal in the United Kingdom.[citation needed]
  • United States: HXE is not illegal, however, if it is sold with the intention for human consumption (such as in capsules) it becomes illegal to possess under the Federal Analogue Act. This is avoided by placing the label "not for human consumption" on the container of the chemical.[citation needed]

See also

External links


  1. "Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien" (in German). Bundeskanzlei [Federal Chancellery of Switzerland]. Retrieved January 1, 2020. 

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