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Summary sheet: Risperidone
Chemical Nomenclature
Common names Risperdal
Substitutive name Risperidone
Systematic name 3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one
Class Membership
Psychoactive class Antipsychotic
Chemical class Benzisoxazole
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.

Threshold 0.25 mg
Light 0.5 - 1 mg
Common 1 - 3 mg
Strong 3 - 6 mg
Heavy 6 mg +
Total 12 - 20 hours
Onset 20 - 60 minutes
Peak 2 - 8 hours
Offset 2 - 4 hours
After effects 12 - 24 hours

DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.


Risperidone (also known as Risperdal) is an atypical antipsychotic medication of the benzisoxazole chemical class. Risperidone is prescribed for bipolar disorder, autism, and psychotic disorders, such as in schizophrenia. It is sometimes used as a sedative to reduce the effects of psychedelics like LSD and to induce sleepiness. Benzodiazepines are also used for this purpose.



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This pharmacology section is incomplete.

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Risperidone has a complex pharmacology, but its main mechanism of action is as a D2 dopaminergic receptor antagonist. This means that it blocks dopamine from binding to the receptor, meanwhile not activating it.[citation needed] It also blocks most of the serotonin receptors, being an inverse agonist at the 5-HT2A, 5-HT2B, and 5-HT2C serotonin receptors.[citation needed] Risperidone has the strongest affinity to the 5-HT2A receptor.[citation needed] On top of that, it acts as an irreversible antagonist at the 5-HT7 serotonin receptor. Its hypnotic effects come from the blockade of dopamine D2 receptors.

Subjective effects

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Physical effects

Cognitive effects

Experience reports

There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:

Toxicity and harm potential


This toxicity and harm potential section is a stub.

As a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it.
Note: Always conduct independent research and use harm reduction practices if using this substance.

Legal status

  • Australia: Risperidone is available only through prescription.[citation needed]
  • Germany: Risperidone is a prescription medicine, according to Anlage 1 AMVV.[1]
  • Switzerland: Risperidone is listed as a "Abgabekategorie B" pharmaceutical, which requires a prescription.[2]
  • United Kingdom: Risperidone is available only through prescription.[citation needed]
  • United States: Risperidone is available only through prescription.[citation needed]

See also

External links


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