Prolintane
| Summary sheet: Prolintane |
| Prolintane | |||||||||||||||||||||||||||||||||
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| Chemical Nomenclature | |||||||||||||||||||||||||||||||||
| Common names | Prolintane | ||||||||||||||||||||||||||||||||
| Substitutive name | Phenylpyrrolidinopentane | ||||||||||||||||||||||||||||||||
| Systematic name | 1-Phenyl-2-pyrrolidinylpentane | ||||||||||||||||||||||||||||||||
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| Psychoactive class | Stimulant | ||||||||||||||||||||||||||||||||
| Chemical class | Amphetamine / Pyrrolidine | ||||||||||||||||||||||||||||||||
| Routes of Administration | |||||||||||||||||||||||||||||||||
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1-Phenyl-2-pyrrolidinylpentane (also known as Prolintane, and by the trade names Catovit, Promotil, and Villescon) is a synthetic central nervous system (CNS) stimulant that is structurally similar to the substituted pyrrolidine class of compounds such as MDPV and A-PVP albeit with notably attenuated effects. Prolintane was first synthesized in the 1950s, where it was found primarily to act as as a norepinephrine-dopamine reuptake inhibitor (NDRI)[1] which is thought to confer its stimulant and potential nootropic qualities.
Historical reports show records of the preparation of prolintane for use as a mild CNS stimulant, wakefulness agent, and cessation aid for cocaine addiction. It has been marketed in Europe since the 1960s as an antidepressant (i.e. due to its anti-fatigue properties) and analeptic. It has a history of being used in neuropsychiatric research related to CNS stimulants with reduced side effects. Therapeutic uses of prolintane in Africa, Europe, and Australia include the treatment of narcolepsy, ADHD, fatigue, and orthostatic hypotension. It is not approved for pharmaceutical use in the United States.[2]
The first reports of prolintane abuse appeared in Europe during the early 2000s when prolintane was identified in tablets distributed at a rave party. Later reports documented the recreational use of prolintane in the United States, where it appears to substitute for recreational amphetamine and other stimulant use.[2]
Chemistry
Prolintane, or 1-Phenyl-2-pyrrolidinylpentane, is a synthetic stimulant of the amphetamine class. An amphetamine molecules has the structure of a phenethylamine molecules with an additional methyl group located on the alpha carbon. Prolintane's structure consists of a phenethylamine core with a propyl group substituted at the alpha carbon, and a pyrrolidine ring at the amino group. Prolintan is structurally similar to A-PVP, but differs in the absence of a ketone group attached to the beta carbon.
Pharmacology
Prolintane is thought to act primarily as a mild norepinephrine-dopamine reuptake inhibitor.[1] Reduced re-uptake of norepinephrine and dopamine results in higher concentrations of the two catecholamine neurotransmitters in the synaptic cleft, or gap between neurons. The result of this reduced reuptake activity is an enhanced and prolonged concentration and resulting post-synaptic effect of dopaminergic and noradrenaline signaling at dopamine and norepinephrine receptors on the receiving neurons. This sudden increase in neurotransmitter concentration in the brain is thought to be responsible for the high that prolintane can induce at higher doses.
Because it acts principally as a catecholaminergic re-uptake inhibitor, prolintane could be considered more like cocaine or methylphenidate than amphetamine in its pharmacological mechanism of action [3] In contrast, amphetamine acts primarily as an agonist to release dopamine and noradrenaline indirectly via activation of the TAAR1 receptor.[citation needed]
Subjective effects
The effects listed below are based upon the subjective effects index and personal experiences of PsychonautWiki contributors. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.
Physical effects 
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- Abnormal heartbeat
- Appetite suppression
- Diarrhea or Nausea - Some experience reports describe individuals who have experienced one or more types of gastrointestinal disturbance while under the influence of prolintane, but typically only at very high doses.
- Headaches
- Increased heart rate - Higher doses of prolintane can create a significant and often dangerous increase in heart rate and blood pressure.
- Muscle contractions
- Muscle spasms
- Restless leg syndrome
- Stamina enhancement
- Stimulation
After effects 
- The effects which occur during the offset of a stimulant experience generally feel negative and uncomfortable in comparison to the effects which occurred during its peak. This is often referred to as a "comedown" and occurs because of neurotransmitter depletion. Its effects commonly include:
Cognitive effects 
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The general cognitive effects of prolintane can be described as being similar to those of classical CNS stimulants with attenuated activity. At common dosages, the prolintane high is described as being subtle and functional, comparable to a proportionally smaller dose of dextroamphetamine with a smoother, less jittery come up and a milder comedown. Higher doses of prolintane, however, can likely intensify numerous negative effects such as anxiety and disorganized thoughts; at extremely high doses or continued use, delusions and psychosis become likely.
- Anxiety
- Cognitive euphoria
- Compulsive redosing
- Creativity enhancement
- Delusions - This effect can manifest with high doses, but less readily than with other stimulants.
- Ego inflation
- Focus enhancement
- Increased libido
- Motivation enhancement
- Paranoia - This effect can also manifest with high doses, but less readily than with other stimulants.
- Stamina enhancement
- Psychosis
- Time distortion - This can be described as the experience of time speeding up and passing much quicker than it usually would when sober.
- Thought acceleration
- Thought organization - Mainly observed with low to common doses.
- Thought disorganization - This effect manifests and is also intensified with higher doses.
- Wakefulness
Experience reports
Anecdotal reports which describe the effects of this compound within our experience index include:
Toxicity and harm potential
The toxicity and long-term health effects of recreational prolintane use do not seem to have been studied in any scientific context, and the exact toxic dosage is unknown. Anecdotal evidence from people who have tried prolintane within the community suggests that there do not seem to be any negative health effects attributed to simply trying this drug at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed).
Lethal dosage
The exact lethal dosage of prolintane is unknown, and no formal studies have been carried out in humans. The typical adult therapeutic dose of prolintane has been 10-40mg daily. In therapeutic trials, 20mg prolintant is a mild stimulant equivalent to 100mg caffeine. In a study of fatigued volunteers the administration of 20mg or 40mg prolintane produced similar, but less intense effects than 20mg d-amphetamine. In experimental studies of healthy volunteers, prolintane has little cardiovascular activity following the single dose of 20mg.[2]
Tolerance and addiction potential
Unlike some of the other more potent stimulants in its class, the chronic use of prolintane can be considered mildly to moderately addictive with only a moderate potential for abuse and is capable of causing psychological dependence among certain users.
When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage. Addiction is a potential risk among users of prolintane as it can cause compulsive redosing, although typically to a far lesser degree than the notoriously compulsive cathinone analogs A-PVP and MDPV.
Psychosis
User reports indicate that chronic abuse or single overdose exposure of prolintane can potentially lead to psychosis. Psychotic symptoms from prolintane can include hearing voices, visual hallucinations, urges to harm oneself, severe anxiety, mania, grandiosity, paranoid delusions, confusion, increased aggression, and irritability.
Dangerous interactions
Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).
Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.
- Stimulants - Prolintane can be potentially dangerous in combination with other stimulants as it can increase one's heart rate and blood pressure to dangerous levels.
- 25x-NBOMe & 25x-NBOH - 25x compounds are highly stimulating and physically straining. Combinations with Prolintane should be strictly avoided due to the risk of excessive stimulation and heart strain. This can result in increased blood pressure, vasoconstriction, panic attacks, thought loops, seizures, and heart failure in extreme cases.
- Alcohol - Combining alcohol with stimulants can be dangerous due to the risk of accidental over-intoxication. Stimulants mask alcohol's depressant effects, which is what most people use to assess their degree of intoxication. Once the stimulant wears off, the depressant effects will be left unopposed, which can result in blackouts and severe respiratory depression. If mixing, the user should strictly limit themselves to only drinking a certain amount of alcohol per hour.
- DXM - Combinations with DXM should be avoided due to its inhibiting effects on serotonin and norepinephrine reuptake. There is an increased risk of panic attacks and hypertensive crisis, or serotonin syndrome with serotonin releasers (MDMA, methylone, mephedrone, etc.). Monitor blood pressure carefully and avoid strenuous physical activity.
- MDMA - Any neurotoxic effects of MDMA are likely to be increased when other stimulants are present. There is also a risk of excessive blood pressure and heart strain (cardiotoxicity).
- MXE - Some reports suggest combinations with MXE may dangerously increase blood pressure and increase the risk of mania and psychosis.
- Dissociatives - Both classes carry a risk of delusions, mania and psychosis, and these risk may be multiplied when combined.
- Stimulants - Prolintane may be dangerous to combine with other stimulants like cocaine as they can increase one's heart rate and blood pressure to dangerous levels.
- Tramadol - Tramadol is known to lower the seizure threshold[4] and combinations with stimulants may further increase this risk.
- MDMA - The neurotoxic effects of MDMA may be increased when combined with amphetamine and other stimulants.
- MAOIs - This combination may increase the amount of neurotransmitters such as dopamine to dangerous or even fatal levels. Examples include syrian rue, banisteriopsis caapi, and some antidepressants.[5]
- Cocaine - This combination may increase strain on the heart.
Legal status
 |
This legality section is a stub. As such, it may contain incomplete or wrong information. You can help by expanding it. |
- Germany: Prolintane is a prescription only medicine, according to Anlage 1 AMVV (Medicine Prescribing Regulation, Schedule 1).[6]
- Switzerland: Prolintane is not controlled under Buchstabe A, B, C and D. It could be considered legal.[7]
See also
- Responsible use
- Research chemical
- Stimulant
- Nootropic
- Substituted pyrrolidine
- Methylphenidate
- a-PVP
- MDPV
External links
References
- ↑ 1.0 1.1 New tertiary amines and their salts and process for their preparation
- ↑ 2.0 2.1 2.2 Moody, D. E. (1 January 2013). "Medical Toxicology of Drug Abuse: Synthesized Chemicals and Psychoactive Plants". Journal of Analytical Toxicology. 37 (1): 50–50. doi:10.1093/jat/bks088. ISSN 1945-2403.
- ↑ http://www.who.int/medicines/areas/quality_safety/4_13_Review.pdf?ua=1
- ↑ Talaie, H.; Panahandeh, R.; Fayaznouri, M. R.; Asadi, Z.; Abdollahi, M. (2009). "Dose-independent occurrence of seizure with tramadol". Journal of Medical Toxicology. 5 (2): 63–67. doi:10.1007/BF03161089. eISSN 1937-6995. ISSN 1556-9039. OCLC 163567183.
- ↑ Gillman, P. K. (2005). "Monoamine oxidase inhibitors, opioid analgesics and serotonin toxicity". British Journal of Anaesthesia. 95 (4): 434–441. doi:10.1093/bja/aei210
. eISSN 1471-6771. ISSN 0007-0912. OCLC 01537271. PMID 16051647.
- ↑ "Anlage 1 AMVV" (in German). Bundesministerium der Justiz und für Verbraucherschutz. Retrieved December 28, 2019.
- ↑ "Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien" (in German). Bundeskanzlei [Federal Chancellery of Switzerland]. Retrieved January 1, 2020.