List of psychoactive substances derived from artificial fungi biotransformation

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List of psychoactive substances derived from artificial fungi biotransformation. These are novel psychedelics with no human safety data available.

Substrates suspected to produce neurotoxic compounds

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4-PO-5-MeO-DMT and 4-PO-5-HO-DMT may be neurotoxic

Compared to related indoles and tryptamines lacking substitutions at the 5,6-position, these new molecules might possess neurotoxic or convulsive properties due to their structure, suggesting potentially shared negative effects.

  • 4-HO-5-MeO-DMT (psilomethoxin) mushrooms derived from Psilocybe cubensis mycelium in substrate with added 5-MeO-DMT.[4][3]
    • Uncertain outcome: There's no guarantee this modification will create the intended compound 4-PO-5-HO-DMT (psilomethoxin). Research (see a 2023 preprint) hasn't been able to confirm psilomethoxin production in lab settings.

See also

External links

References

  1. 1.0 1.1 Gartz J (1989). "Biotransformation of tryptamine derivatives in mycelial cultures of Psilocybe". Journal of Basic Microbiology. 29 (6): 347–52. doi:10.1002/jobm.3620290608. PMID 2614674.  Unknown parameter |s2cid= ignored (help)
  2. "Read #16 4-HO-DET | TiHKAL · info". isomerdesign.com. 
  3. 3.0 3.1 3.2 "Ask Dr. Shulgin Online: 4-Hydroxy-5-methoxy-N,N-dimethyltryptamine, Psilocybe mushrooms, Psilocin" (in English). 
  4. Julia M, Manoury P, Voillaume MC (1965). "[No 209 - Recherches en série indolique. XIV (*) - Sur des méthoxy-5 hydroxy-4, méthoxy-5 hydroxy-6 et méthoxy-7 hydroxy-6 tryptamines]". Bull Chim Soc Fr (in French): 1417–23.