4-HO-DPT

Summary sheet: 4-HO-DPT

4-HO-DPT
Chemical Nomenclature
Common names	4-HO-DPT, Procin
Substitutive name	4-Hydroxy-N,N-dipropyltryptamine
Systematic name	3-[2-(dipropylamino)ethyl]-1H-indol-4-ol
Class Membership
Psychoactive class	Psychedelic
Chemical class	Tryptamine
Routes of Administration
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. ⇣ Oral Dosage Threshold 20 mg Light 40 - 60 mg Common 60 - 90 mg Strong 90 - 130 mg Heavy 130 mg + Duration Total 5 - 8 hours Onset 45 - 60 minutes Come up 60 - 120 minutes Peak 2 - 3 hours Offset 1 - 2 hours ⇣ Insufflated Dosage Threshold 5 mg Light 10 - 15 mg Common 15 - 25 mg Strong 25 - 35 mg Heavy 35 mg + Duration Total 4 - 6 hours Onset 15 - 45 minutes Come up 30 - 45 minutes Peak 1 - 3 hours Offset 1 - 2 hours DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.
Interactions
Cannabis
Stimulants
Tramadol
Lithium

4-HO-DPT (also known as 4-hydroxy-N,N-dipropyltryptamine and sometimes referred to as Procin) is a psychedelic substance of the tryptamine class. Alexander Shulgin first synthesized 4-HO-DPT and documented it in his book TiHKAL (Tryptamines I Have Known and Loved). It is the 4-hydroxyl analog of DPT.

Today it is either used recreationally or as an entheogenic compound and is typically acquired through the use of online research chemical vendors. Due to the difficulty of its synthesis, it remains relatively uncommon even for a substituted tryptamine and has very little history of human usage.

Chemistry

4-HO-DPT, or 4-hydroxy-N,N-dipropyltryptamine, is a synthetic indole molecule of the tryptamine class. Tryptamines share a core structure comprised of a bicyclic indole heterocycle attached at R₃ to an amino group via an ethyl side chain. 4-HO-DPT is substituted at R₄ of its indole heterocycle with a hydroxyl functional group OH−. It also contains two propyl chains bound to the terminal amine R_N of its tryptamine backbone (DPT).

4-HO-DPT is a 4-hydroxy analog of 4-AcO-DPT and the N-substituted dipropyl homolog of psilocin (4-HO-DMT).

Pharmacology

Further information: Serotonergic psychedelic

Like with most psychedelic tryptamines, 4-HO-DPT is thought to act principally as a 5-HT_2A partial agonist. The psychedelic effects are believed to come from 4-HO-DPT's binding efficacy at the 5-HT_2A receptors. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Subjective effects

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

In comparison to other tryptamines such as 4-AcO-DMT and 4-HO-DMT, it is extremely similar in terms of its visual, cognitive and physical effects although it feels somewhat less natural and slightly more synthetic. It is also worth noting that it lacks the extremely uncomfortable physical side effects which are present within its close structural relative DPT. This allows it to feel far more similar to that of a generic or classical substituted tryptamine such as psilocin.

Physical effects

• • Spontaneous physical sensations
  • Bodily control enhancement
  • Increased heart rate
  • Nausea
  • Sedation
  • Pupil dilation
  • Tactile enhancement
  • Mouth numbing
  • Physical euphoria
  • Muscle relaxation

Visual effects

• Enhancements

  • Colour enhancement
  • Pattern recognition enhancement
  • Visual acuity enhancement

  Suppressions

  • Visual acuity suppression

  Distortions

  • Drifting (melting, breathing, morphing and flowing)
  • Colour shifting
  • Depth perception distortions
  • Perspective distortions
  • Symmetrical texture repetition
  • Tracers
  • After images
  • Brightness alteration
  • Diffraction
  • Scenery slicing

  Geometry

  Hallucinatory states

  • Internal hallucination (autonomous entities; settings, sceneries, and landscapes; perspective hallucinations and scenarios and plots)

Cognitive effects

• • Analysis enhancement
  • Conceptual thinking
  • Cognitive euphoria
  • Delusion
  • Emotion enhancement
  • Immersion enhancement
  • Increased music appreciation
  • Memory suppression
    • Ego death
  • Novelty enhancement
  • Personal bias suppression
  • Thought acceleration
  • Thought loops
  • Time distortion
  • Unity and interconnectedness
  • Laughter
  • Language suppression
  • Mindfulness

Auditory effects

• • Enhancements
  • Distortions
  • Hallucinations

Experience reports

There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:

• Erowid Experience Vaults: 4-HO-DPT

Toxicity and harm potential

Further information: Research chemicals § Toxicity and harm potential, and Responsible use § Hallucinogens

The toxicity and long-term health effects of recreational 4-HO-DPT use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because 4-HO-DPT is a research chemical with very little history of human usage. Anecdotal evidence from people within the psychonaut community who have tried 4-HO-DPT suggests that there are no negative health effects attributed to simply trying the drug by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use harm reduction practices when using this drug.

Tolerance and addiction potential

4-HO-DPT is not habit-forming, and the desire to use it can actually decrease with regular consumption. Like with most psychedelics, it is most often thought to be self-regulating.

Tolerance to the effects of 4-HO-DPT is built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). 4-HO-DPT presents cross-tolerance with all psychedelics, meaning that after the consumption of 4-HO-DPT all psychedelics will have a reduced effect.

Dangerous interactions

Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

• Lithium - Lithium is commonly prescribed for the treatment of bipolar disorder. There is a large body of anecdotal evidence that suggests taking it with psychedelics significantly increases the risk of psychosis and seizures. As a result, this combination is strictly discouraged.
• Cannabis - Cannabis may have an unexpectedly strong and unpredictable synergy with the effects of 4-HO-DPT. Caution is advised with this combination as it can significantly increase the risk of adverse psychological reactions like anxiety, paranoia, panic attacks, and psychosis. Users are advised to start off with only a fraction of their normal cannabis dose and take long breaks between hits to avoid unintentional overdose.
• Stimulants - Stimulants like amphetamine, cocaine or methylphenidate affect many parts of the brain and alter dopaminergic function. This combination can increase the risk of anxiety, paranoia, panic attacks, and thought loops. This interaction may also result in an elevated risk of mania and psychosis.
• Tramadol - Tramadol is well-documented to lower the seizure threshold and psychedelics may act to trigger seizures in susceptible individuals.

Legal status

Due to its relative obscurity, 4-HO-DPT is unscheduled in most countries.

• Germany: 4-HO-DPT is controlled under the NpSG (New Psychoactive Substances Act) as of July 18, 2019. Production and import with the aim to place it on the market, administration to another person, placing it on the market and trading is punishable. Possession is illegal but not punishable. The legislator considers it possible that orders of 4-HO-DPT are punishable as an incitement to place it on the market.
• Sweden: 4-HO-DPT is classified as a "dangerous substance", which means it requires a special permit to buy or sell. It is, however, not yet classified as a drug.
• Switzerland: 4-HO-DPT is not controlled under Buchstabe A, B, C and D. It could be considered legal.
• United Kingdom: 4-HO-DPT is a Class A drug in the United Kingdom as a result of the tryptamine catch-all clause.
• United States: 4-HO-DPT is unscheduled in the United States. It may be considered an analogue of psilocin (which is a Schedule I drug under the Controlled Substances Act). As such, the sale for human consumption or could be prosecuted as crimes under the Federal Analogue Act.

See also

• Responsible use
• Research chemical
• DPT
• 4-HO-DMT
• 4-HO-MiPT
• 4-HO-MET
• Tryptamine

External links

• 4-HO-DPT (Wikipedia)
• 4-HO-DPT (TiHKAL / Isomer Design)
• 4-HO-DPT (Bluelight)