Talk:Amisulpride

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Summary sheet: Amisulpride

Amisulpride
Chemical Nomenclature
Common names	Amisulpride, Solian, Barhemsys
Systematic name	4-amino-N-[(1-ethylpyrrolidin-2-yl)methyl]-5-ethylsulfonyl-2-methoxybenzamide
Class Membership
Psychoactive class	Antipsychotic
Chemical class	Benzamide
Routes of Administration
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. ⇣ Oral Dosage Bioavailability 48% Threshold 25 mg Light 50 - 100 mg Common 100 - 200 mg Strong 200 - 300 mg Heavy 300 mg + Duration Total 12 - 24 hours Onset 20 - 40 minutes Peak 1.5 - 6 hours Offset 8 - 12 hours After effects 24 - 48 hours DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

Amisulpride (also known under brand names including Solian and Barhemsys) is a atypical antipsychotic substance of the benzamide class.

History and culture

This History and culture section is a stub. As a result, it may contain incomplete or wrong information. You can help by expanding it.

Chemistry

This chemistry section is incomplete. You can help by adding to it.

Amisulpride is the 4-position amino substitution of sulpiride which in turn is based on a benzamide core.

Pharmacology

Amisulpride primarily works by antagonising D₂ and D₃ dopamine receptors in the limbic system as well as antagonising 5-HT₇, 5-HT_2A and 5-HT_2B serotonin receptors.

At dosages between 50 - 300mg, there has been shown to be a significant therapeutic effect of the negative symptoms of acute and chronic schizophrenia, which is due to the substance then primarily acting as a selective antagonist of the pre-synaptic dopamine autoreceptors. This blockage in turn increases the release of Dopamine.

At higher dosages, ranging from 400 up to 1200mg, positive symptoms, such as loss of reality, delusions, delirium and hallucinations are known to decrease, as amisulpride now blocks the post-synaptic dopamine receptors.

The selectivity of amisulpride in the limbic system also explain why it is less likely to get extrapyramidal symptoms in comparison to other antipsychotics, which tend to express their effects less selectively or primarily in the stratium.

The action upon the 5-HT₇ receptors is thought to have uplifting and antidepressant rather than sedating and depressing effects, which make it rather unique upon antipsychotic medications.

Subjective effects

This subjective effects section is a stub. As such, it is still in progress and may contain incomplete or wrong information. You can help by expanding or correcting it.

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Physical effects

• • Sedation or Stimulation - Depending on the dosage and individual reaction, amisulpride can work either sedating or stimulation. Amisulpride is generally known to be mood increasing and being effective as an atypical antidepressant for people with negative Schizophrenic symptoms such as isolation, emotion suppression, depression which makes it very unique among antipsychotics. This properties which appear at dosages from 50-300mg are well researched. Dosages from 400mg to 1200mg are more known to act against the positive symptoms of schizophrenia, which include internal hallucinations, external hallucinations, delusions and of course psychosis as well as thought disorganization. Antidepressive Effects are known to be found at all dosages, due to 5HT₇ antagonism.
  • Increased salivation
  • Headaches
  • Increased prolactin - This can potentially cause the absence of the menstrual cycle, breast enlargement, breast milk secretion not related to breastfeeding, impaired fertility, impotence, breast pain, benign tumors and even more. Amisulpride is one of the antipsychotics known to have the highest impact on prolactin increase.
  • Abnormal heartbeat - This effect can increase with the dosage. Amisulpride is known to cause a prolongation of the QT interval which could possibly lead to sudden death, especially in suspectable individuals or when combined with other medications affecting the QT interval such as many antihistamines and antipsychotics.

Cognitive effects

• • Thought deceleration or Thought acceleration - This is depending on the dosage and the currently occurring schizophrenic and psychotic situation of the individual which often lead to thought disorders and thought disorganization. Amisulpride can have a rebalancing effect, which may also depends on the dosage.
  • Dream potentiation
  • Depression reduction - This can occur due to the dopaminergic increase on the lower dosages (50 - 300mg) where the negative symptoms such as depression in primarily schizophrenic individuals can be mediated, although this effect can also persist in individuals with normal depression. The 5-HT₇ receptor antagonism along all dosages is thought to produce this effect.
  • Euphoria - This can be felt in individuals who have strong psychotic and schizophrenic effects due to relieve of their negative and or positive symptoms.

After effects

• • Nausea - As amisulpride also works as an antiemetic, a sudden withdrawal from higher dosages without titration can induce the opposite effects.
  • Vomiting - Sudden withdrawal after prolonged use can induce vomiting due to disappearing antiemetic properties.

Experience reports

There are currently 0 experience reports which describe the effects of this substance in our experience index.

Additional experience reports can be found here:

• Erowid Experience Vaults: Amisulpride

Toxicity and harm potential

This toxicity and harm potential section is a stub. As a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it. Note: Always conduct independent research and use harm reduction practices if using this substance.

It is strongly recommended that one use harm reduction practices when using this substance.

Dangerous interactions

This dangerous interactions section is a stub. As such, it may contain incomplete or invalid information. You can help by expanding upon or correcting it.

Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

Legal status

This legality section is a stub. As such, it may contain incomplete or wrong information. You can help by expanding it.

• Austria: Amisulpride is a prescription only drug.
• Australia: Amisulpride is a Schedule 4 prescription only drug.
• Brazil: Amisulpride is a Class C1 prescription only drug.
• United Kingdom: Amisulpride is a prescription only drug.
• United States: Amisulpride is a prescription only drug.

See also

• Responsible use

External links

• Amisulpride (Wikipedia)
• Amisulpride (Isomer Design)
• Amisulpride (DrugBank)
• Amisulpride (Drugs.com)