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Antipsychotics (also known as neuroleptics or major tranquilizers)[1] are a class of psychiatric medication primarily used to manage psychosis (including delusions, hallucinations, or disordered thought), particularly in schizophrenia, bipolar disorder, and as an add on treatment in some cases of major depressive disorder.

First generation antipsychotics, known as typical antipsychotics, were discovered in the 1950s. Most second generation drugs, called atypical antipsychotics, have been developed more recently. The first atypical antipsychotic, clozapine, was discovered in the 1950s and introduced clinically in the 1970s. Both generations of medication tend to block receptors in the brain's dopamine pathways; atypicals tend to act on serotonin receptors as well.

Notable and relatively common adverse effects of antipsychotics include extrapyramidal symptoms (which involve motor control and are very serious), hyperprolactinaemia (primarily in typicals), weight gain and metabolic abnormalities (mostly in atypicals).[2]


First-generation (typical) antipsychotics

Second-generation (atypical) antipsychotics

Third-generation antipsychotics

See also

External links


  1. Finkel, R., Clark, M. A., Cubeddu, L. X. (2009). Pharmacology. Lippincott Williams & Wilkins. ISBN 9780781771559. 
  2. Frankenburg, F. R.; Dunayevich, E.; Albucher, R. C.; Talavera, F. "Schizophrenia". Retrieved 2013-10-02.