Methallylescaline

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Summary sheet: Methallylescaline
Methallylescaline
Methallylescaline.svg
Chemical Nomenclature
Common names Methallylescaline, MAL
Substitutive name 4-methallyloxy-3,5-dimethoxyphenethylamine
Systematic name 2-(3,5-dimethoxy-4-[(2-methylprop-2-en-1-yl)oxy]phenyl)ethanamine
Class Membership
Psychoactive class Psychedelic
Chemical class Phenethylamine
Routes of Administration

WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.



Oral
Dosage
Threshold 5 mg
Light 15 - 25 mg
Common 25 - 40 mg
Strong 40 - 60 mg
Heavy 60 mg +
Duration
Total 6 - 12 hours
Onset 20 - 60 minutes
Come up 30 - 90 minutes
Peak 3 - 5 hours
Offset 2 - 4 hours
After effects 4 - 8 hours









DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

Interactions


4-Methallyloxy-3,5-dimethoxyphenethylamine (also known as methallylescaline and MAL) is a synthetic psychedelic substance of the phenethylamine chemical class. It is reported to produce hallucinogenic and stimulant effects comparable to that of other mescaline analogs (e.g. allylescaline, proscaline, and escaline) when administered.

The effects of methallylescaline were first described by Alexander Shulgin in his book PiHKAL: A Chemical Love Story. He lists the dosage range as 40mg to 60mg orally and describes the duration of action to be 8 - 12 hours.[1] Anecdotal reports portray that methallylescaline bears the most similarity to mescaline, although higher dosages can produce a strong body load.

Very little data exists about the pharmacological properties, metabolism, and toxicity of methallylescaline, and it has little history of human usage. It is highly advised to use harm reduction practices if using this substance.

Chemistry

Generic structure of a phenethylamine molecule

Methallylescaline, or 4-methallyloxy-3,5-dimethoxyphenethylamine, is a substituted phenethylamine featuring a phenyl ring bound to an amino (NH2) group through an ethyl chain. Methallylescaline contains two methoxy functional groups (CH3O-) which are attached to carbons R3 and R5 of the phenyl ring.

Methallylescaline is substituted at R4 with a methallyloxy chain. This three carbon chain consists of a R2 methyl substituted allyl group with a double bond on the terminal carbon. This chain is connected to the phenyl ring at R4 through an ether (oxygen) bridge.

Pharmacology

Further information: Serotonergic psychedelic

Methallylescaline likely acts as a 5-HT2A partial agonist. The psychedelic effects are believed to come from methallylescaline's efficacy at the 5-HT2A receptors. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

Subjective effects

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This subjective effects section is a stub.

As such, it is still in progress and may contain incomplete or wrong information.

You can help by expanding or correcting it.

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.


Physical effects
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Visual effects
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Experience reports

There are currently no anecdotal reports which describe the effects of this compound within our experience index. Additional experience reports can be found here:

Toxicity and harm potential

The toxicity and long-term health effects of recreational methallylescaline use do not seem to have been studied in any scientific context and the exact toxic dose is unknown. This is because methallylescaline is a research chemical with very little history of human usage.

Anecdotal evidence suggests that there are no negative health effects attributed to simply trying the substance by itself at low to moderate doses and using it very sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.

It is strongly recommended that one use harm reduction practices when using this substance.

Tolerance and addiction potential

Methallylescaline is not habit-forming, and the desire to use it can actually decrease with use. It is most often self-regulating.

Tolerance to the effects of methallylescaline is built almost immediately after ingestion. After that, it takes about 3 days for the tolerance to be reduced to half and 7 days to be back at baseline (in the absence of further consumption). Methallylescaline presents cross-tolerance with all psychedelics, meaning that after the consumption of methallylescaline all psychedelics will have a reduced effect.

Legal status

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This legality section is a stub.

As such, it may contain incomplete or wrong information. You can help by expanding it.

  • Canada: Methallylescaline is not listed under the Controlled Drugs and Substances Act, so it is technically not illegal.[citation needed]
  • Germany: Methallylescaline is controlled under the NpSG[2] (New Psychoactive Substances Act) as of November 26, 2016.[3] Production and import with the aim to place it on the market, administration to another person, placing it on the market and trading is punishable. Possession is illegal but not punishable.[4][5] The legislator considers it possible that orders of methallylescaline are punishable as an incitement to place it on the market.[6]
  • Switzerland: Methallylescaline is a controlled substance specifically named under Verzeichnis E.[7]
  • United Kingdom: Methallylescaline is illegal to produce, supply, or import under the Psychoactive Substance Act, which came into effect on May 26th, 2016.[8]
  • United States: Methallylescaline is unscheduled in the United States, but may be considered an analogue of mescaline under the Federal Analogue Act.[citation needed]

See also

External links

Discussion

References

  1. Alexander Shulgin; Ann Shulgin (1991). "#99. MAL". PiHKAL: A Chemical Love Story. United States: Transform Press. ISBN 0963009605. OCLC 1166889264. 
  2. "Anlage NpSG" (in German). Bundesamt für Justiz [Federal Office of Justice]. Retrieved December 10, 2019. 
  3. "Gesetz zur Bekämpfung der Verbreitung neuer psychoaktiver Stoffe" (PDF). Bundesgesetzblatt Jahrgang 2016 Teil I Nr. 55 (in German). Bundesanzeiger Verlag (published November 25, 2016). November 21, 2016. pp. 2615–2622. ISSN 0341-1095. OCLC 1004462279. 
  4. "§ 4 NpSG" (in German). Bundesamt für Justiz [Federal Office of Justice]. Retrieved December 10, 2019. 
  5. "§ 3 NpSG" (in German). Bundesamt für Justiz [Federal Office of Justice]. Retrieved December 10, 2019. 
  6. "Gesetzentwurf der Bundesregierung: Entwurf eines Gesetzes zur Bekämpfung der Verbreitung neuer psychoaktiver Stoffe" (PDF) (in German). Deutscher Bundestag. May 30, 2016. p. 20. Drucksache 18/8579. 
  7. "Verordnung des EDI über die Verzeichnisse der Betäubungsmittel, psychotropen Stoffe, Vorläuferstoffe und Hilfschemikalien" (in German). Bundeskanzlei [Federal Chancellery of Switzerland]. Retrieved January 1, 2020. 
  8. "Psychoactive Substances Act 2016". UK Government. Retrieved January 1, 2020.