2C-x

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The general structure for a 2C-x compound

Substituted dimethoxyphenethylamines (also known as 2C-x) is the general name for the family of psychedelic phenethylamines originally studied by Alexander Shulgin. Shulgin first synthesized most of the 2C-x chemicals in the 1970s and later published his findings in his book PiHKAL. He also coined the term 2C, being an acronym for the 2 carbon atoms between the benzene ring and the amino group. The 2C-x chemicals vary in effect from being totally inactive to fully psychedelic. Some of the most popular members of this group include 2C-B, 2C-E, and 2C-I.

Chemistry

Molecule.svg

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You can help by adding to it.

All derivatives of 2,5-dimethoxyphenethylamine have a phenethylamine backbone with two methoxy groups in positions 2 and 5 of the aromatic ring and they further contain different lipophilic substituents in position 4.

The phenethylamine backbone consists of a phenyl ring joined to an amine group through an ethyl chain. All compounds in the 2C-x series consist of this as their core structure.

List of 2C-x compounds

Note: This list does not include 2C-T-x, 25x-NBOH, 25x-NBOMe, DOx.

Classic 2C-x compounds

Compound R4 Structure
2C-H H 2C-H.svg
2C-B Br 2C-B.svg
2C-C Cl 2C-C.svg
2C-D CH3 2C-D.svg
2C-E CH2CH3 2C-E.svg
2C-I I 2C-I.svg
2C-iP CH(CH3)2 2C-iP.svg
2C-P CH2CH2CH3 2C-P.svg
2C-TFM CF3 2C-TFM.svg

Other compounds, derivated from 2,5-dimethoxyphenethylamine

Compound R3 R4 R6 Rβ Structure
BOD H CH3 H OCH3 BOD.svg
βk-2C-B H Br H =O Βk-2C-B.svg
2C-B-FLY CH2- Br CH2- H 2C-B-FLY.svg

Toxicity and harm potential

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This toxicity and harm potential section is a stub.

As a result, it may contain incomplete or even dangerously wrong information! You can help by expanding upon or correcting it.
Note: Always conduct independent research and use harm reduction practices if using this substance.

The 2C-x chemicals, as with many other serotonergic psychedelics, should not be taken in combination with SSRIs (selective serotonin reuptake inhibitor) or tricyclic antidepressants in general to avoid serotonin syndrome, a potentially life-threatening condition in which an abundance of serotonin is built up the body, causing many physical and cognitive health problems.

Dangerous interactions

Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).

Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.

  • 5-meo-xxt - The 5-MeO psychedelics can interact unpredictably to potentiate other psychedelics
  • amphetamines - The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally unnecessary because of the stimulating effects of psychedelics. Combination of the stimulating effects may be uncomfortable.
  • cannabis Cannabis has a strong, volatile synergy with psychedelics. While often used to intensify or prolong their effects, the combination increases the risk of adverse psychological effects like anxiety, paranoia, panic attacks, and psychosis. Anecdotal reports often describe cannabis use as the triggering event for a bad trip or psychosis. Caution is advised.
  • cocaine - The anxiogenic and focusing effects of stimulants increase the chance of unpleasant thought loops. The combination is generally unnecessary because of the stimulating effects of psychedelics. Combination of the stimulating effects may be uncomfortable.
  • maois - MAO-B inhibitors can increase the potency and duration of phenethylamines unpredictably"]

nbomes NBOMes and NBOHs can both cause vasoconstriction and stimulation. The combination is generally unnecessary because of the stimulating effects of psychedelics (the 2C-x series in particular.) Combination of the stimulating effects may be uncomfortable.

  • tramadol - Tramadol is well known to lower seizure threshold and psychedelics raise the risk of seizures.
  • amt

Legal status

  • Austria: The 2C-x family is illegal to possess, produce and sell under the SMG (Suchtmittelgesetz Österreich) or the NPSG (Neue-Psychoaktive-Substanzen-Gesetz Österreich).[citation needed]
  • USA: In the US, most of the 2C-x chemicals are Schedule I under the American Food and Drug Administration Safety and Innovation Act of 2012 and the Federal Analogue Act.[1]
  • Australia: Australia has a blanket ban over all substituted phenethylamines including the entire 2C-X family.[2]
  • Switzerland: Most 2C-x drugs are illegal to possess, produce and sell.[3]
  • Canada: All 2C-x phenethylamines are schedule III in Canada. [4]
  • United Kingdom: Most of the 2C-x chemical class are Class A drugs in the United Kingdom as a result of the phenethylamine catch-all clause.[5]
  • Germany: Most 2C-x compounds are controlled under BtMG Anlage I, making them illegal to manufacture, import, possess, sell, or transfer them without a license.[6] Other 2C-x compounds are controlled by the NpSG, as they are derivatives of 2-Phenethylamine. Production, and sale is illegal. Possession and import, although illegal, is not penalized if intended for self-consumption.[7]

See also

External links

Literature

  • Dean, B. V., Stellpflug, S. J., Burnett, A. M., & Engebretsen, K. M. (2013). 2C or not 2C: Phenethylamine Designer Drug Review. Journal of Medical Toxicology, 9(2), 172-178. https://doi.org/10.1007/s13181-013-0295-x

References