Talk:Substituted amphetamines

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Amphetamine behavior effects seem to be dependent on a small a-MT-sensitive pool of catecholamines in the brain

(Catecholamines include epinephrine (adrenaline), norepinephrine (noradrenaline), and dopamine.)

"Previous studies in rats have shown that the central excitatory effects of amphetamine are blocked or reduced by pretreatment with a-methyl-p-tyrosine (a-MT), an inhibitor of tyrosine hydroxylase. 21 , 26, 27 For its various behavioral effects amphetamine seems to be dependent on the presence of a small a-MT-sensitive pool of catecholamines in the brain. 7 , 13, 14, 23 Amphetamine, when injected intravenously to subjects who abuse it, creates specific dose-related euphoric sensations, the intensity of which can be registered by a self-rating technique.'7 Using this experimental design, a-MT has been shown to reduce or abolish the effects of large intravenous doses of amphetamine. 12 17 This paper attempts to define precise dosage, duration, and other characteristics of a-MT blockade of amphetamine in such subjects."