O-Desmethyltramadol/Summary

Main article: O-Desmethyltramadol

Psychoactive class: Opioids

Chemical class: Phenylpropylamine

Oral

• Thresh				Common				Heavy
  5	-	10	-	25	-	50	-	100	mg
  		Light				Strong

• • Total: 6 - 10 hours
  • Onset: 20 - 40 minutes
  • Come up: 30 - 40 minutes
  • Peak: 2 - 5 hours
  • Offset: 2 - 4 hours
  • Afterglow: 1 - 3 hours

Sublingual

• Thresh				Common				Heavy
  5	-	10	-	25	-	50	-	80	mg
  		Light				Strong

• • Total: 5 - 10 hours
  • Onset: 20 - 40 minutes
  • Peak: 2 - 5 hours
  • Offset: 2 - 4 hours
  • Afterglow: 1 - 3 hours

Intravenous

• Thresh				Common				Heavy
  5	-	5	-	12.5	-	25	-	50	mg
  		Light				Strong

• • Total: 5 - 8 hours
  • Onset: 10 - 15 seconds
  • Peak: 2 - 5 hours
  • Offset: 2 - 4 hours
  • Afterglow: 1 - 3 Hours

Harm potential

• • Moderately addictive with a high potential for abuse
  • Moderate potential toxicity relative to its dose due to its potency, potentially lethal when mixed with depressants like alcohol or benzodiazepines

Tolerance

• • Full tolerance is reached develops with prolonged and repeated use
  • Decreases to half after 3 - 7 days
  • Returns to baseline after 1 - 2 weeks
  • Cross-tolerance with all other opioids

Physical effects

• • Appetite suppression
  • Cough suppression
  • Pain relief
  • Respiratory depression
  • Sedation
• • Constipation
  • Difficulty urinating
  • Itchiness
  • Nausea
  • Respiratory depression

Cognitive effects

• • Cognitive euphoria
  • Compulsive redosing
• • Anxiety suppression

See also

• Responsible use
• Summary index
• Subjective effect index
• Psychoactive substance index