Nicotine/Summary

Main article: Nicotine

Psychoactive class: Stimulants, Depressant

Chemical class: Pyridine, Substituted pyrrolidines

Oral

• Thresh				Common				Heavy
  0.2	-	1	-	3	-	5	-	7	mg
  		Light				Strong

• • Total: 5 - 7 hours
  • Onset: 20 - 40 minutes
  • Come up: 60 - 90 minutes
  • Peak: 60 - 90 minutes
  • Offset: 2.5 - 3.5 hours
  • Afterglow: 2 - 4 hours

Buccal

• Thresh				Common				Heavy
  0.2	-	0.5	-	2	-	4	-	6	mg
  		Light				Strong

• • Total: 45 - 90 minutes
  • Onset: 3 - 15 minutes
  • Come up: 3 - 15 minutes
  • Peak: 5 - 20 minutes
  • Offset: 1 - 2 hours
  • Afterglow: 2 - 6 hours

Smoked

• Thresh				Common				Heavy
  0.2	-	0.3	-	0.8	-	1.5	-	3.5	mg
  		Light				Strong

• • Total: 1 - 3 hours
  • Onset: 5 - 20 seconds
  • Come up: 5 - 10 seconds
  • Peak: 2 - 5 minutes
  • Offset: 1 - 2 hours
  • Afterglow: 1 - 3 hours

Harm potential

• • Extremely addictive with a high potential for abuse
  • Estimated oral LD₅₀ of 6.5 - 13 mg/kg in humans

Tolerance

• • Full tolerance is reached rapidly develops with prolonged and repeated use
  • Decreases to half after 3 - 7 days
  • Returns to baseline after 1 - 2 weeks

Physical effects

• • Stimulation
• • Appetite suppression
  • Sedation
• • Abnormal heartbeat
  • Dizziness
  • Dry mouth
  • Increased blood pressure
  • Increased heart rate
  • Increased perspiration
  • Increased salivation
  • Nausea
  • Vasoconstriction

Cognitive effects

• • Cognitive euphoria
  • Compulsive redosing
• • Empathy, affection and sociability enhancement
  • Increased libido
  • Increased music appreciation
  • Memory enhancement
  • Motivation enhancement
• • Anxiety suppression

See also

• Responsible use
• Summary index
• Subjective effect index
• Psychoactive substance index