Talk:N-Desethylisotonitazene

Fatal overdose may occur when opiates are combined with other depressants such as benzodiazepines, barbiturates, gabapentinoids, thienodiazepines, alcohol or other GABAergic substances.

It is strongly discouraged to combine these substances, particularly in common to heavy doses.

Summary sheet: N-Desethylisotonitazene

N-Desethylisotonitazene
Chemical Nomenclature
Common names	NDI
Substitutive name	N-Desethylisotonitazene
Systematic name	N-ethyl-2-[5-nitro-2-[(4-propoxyphenyl)methyl]benzimidazol-1-yl]ethanamine
Class Membership
Psychoactive class	Opioid
Chemical class	Nitazene
Routes of Administration
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section. ⇣ Oral Dosage Threshold 1 μg Light 1 - 5 μg Common 5 - 10 μg Strong 10 - 20 μg Heavy 20 μg + Duration ⇣ Insufflated Dosage Threshold mg Light - mg Common - mg Strong - mg Heavy mg + Duration DISCLAIMER: PW's dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

N-Desethylisotonitazene (commonly referred to as NDI or Norisotonitazene) is a highly potent opioid that belongs to the benzimidazole group. It is an extremely strong agonist at the μ-opioid receptors and is considered to have a potency greater than that of fentanyl, although specific potency comparisons remain ambiguous due to limited data and research.

Unlike traditional pharmaceutical opioids, NDI has no recognized medical use and is typically encountered in the research chemical or illicit drug market. It is commonly found in powder, tablet, or counterfeit pill forms. Due to its potent nature, even slight miscalculations in dosing can result in life-threatening respiratory depression, leading to fatal overdoses. Cases of overdose and fatalities associated with the nitazene class of opioids, including NDI, have seen an increase recently.

Subjective effects include pain relief (analgesia), sedation, respiratory depression, and euphoria. NDI has a rapid onset and short duration of action compared to other opioids, which can lead to compulsive redosing. Some users report that the euphoric effects of NDI are less intense than opioids like heroin or morphine. This observation is consistent with reports within the nitazene class, though subjective effects can vary. Commonly, the experience is described as highly sedative with potent pain-relieving effects, alongside significant respiratory depression. While the onset can feel euphoric, it often escalates to a dissociative or overwhelming intensity, with users often experiencing strong sedation and emotional numbness. This makes it generally less appealing for recreational use.

It’s essential to note that the risks tied to potent opioids like NDI are substantial, with the possibility of accidental overdose being a real and prevalent danger. If you choose to use NDI, it's crucial to take extreme caution regarding its dosage and to test substances for purity and adulterants using reagent testing kits.

History and cultural context

The nitazene opioids, including NDI, are relatively new substances that have emerged on the illicit market as powerful alternatives to traditional opioids. While they are structurally related to older opioids, such as fentanyl, they were synthesized more recently with the goal of achieving stronger pain relief. Their potent effects have made them dangerous to users, and reports of overdoses have surged as these substances have grown in popularity.

Chemical Structure

NDI belongs to the benzimidazole class of opioids. Its chemical structure is characterized by a nitrogen-containing heterocyclic ring, which is responsible for its potent interaction with the μ-opioid receptor. Its high potency is partly attributed to its ability to cross the blood-brain barrier quickly, resulting in rapid onset effects.

Pharmacology

Like many opioids, NDI produces its primary effects by mimicking natural endorphins, neurotransmitters that regulate pain and pleasure in the body. The substance interacts predominantly with the μ-opioid receptor, inducing feelings of euphoria, pain relief, and sedation. However, its potency is much higher than most traditional opioids, which makes it especially dangerous.

Subjective effects

Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.

It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death ☠.

Physical effects

• • Sedation - NDI induces profound sedation, often stronger than common opioids such as heroin or oxycodone.
  • Pain relief - NDI is extremely effective in relieving pain, potentially more so than traditional opioids.
  • Physical euphoria - While not as intense as heroin, NDI can still provide a powerful sense of physical comfort and warmth.
  • Respiratory depression - Even small doses of NDI can cause severe respiratory depression, a primary cause of death in opioid overdoses.
  • Constipation
  • Nausea
  • Itchiness - Some users report itchiness, but this is less pronounced than with other opioids.
  • Decreased blood pressure

Cognitive effects

• • Cognitive euphoria - NDI can induce a sense of overwhelming emotional euphoria, though it is often accompanied by heavy sedation.
  • Anxiety reduction - Like most opioids, NDI is capable of reducing anxiety and providing mental relaxation.
  • Compulsive redosing - Due to its short duration, users may be tempted to redose frequently, which increases the risk of overdose.

Visual effects

• Visual effects

  • Blurred vision - Some individuals report visual distortion or blurring of vision, particularly at higher doses.

Toxicity and harm potential

NDI's potency poses an extremely high risk to users, particularly those without opioid tolerance. Overdoses can happen quickly, and respiratory depression is the leading cause of death. Similar to fentanyl, the risk is exacerbated when the substance is mixed with other depressants, such as alcohol or benzodiazepines.

Because of the difficulty in accurately dosing such a potent substance, users are strongly urged to test their substances and proceed with caution. Even small miscalculations in dosage can lead to fatal consequences, as the difference between a safe dose and an overdose is incredibly small.

At higher doses, NDI may also induce nausea and vomiting, with the risk of aspiration if the user is unconscious or semi-conscious. Users should ensure they are lying on their side to mitigate the risk of suffocation due to vomiting.